You can travel to Cuenca by AVE or ALVIA trains from Madrid (1 h), Valencia (1 h) and Alicante (1 h 30min). Find all the information in Renfe. From the train station (Cuenca Fernando Zóbel) to downtown Cuenca you can take bus #12 (to the bus station) or a cab (15 minutes).
You can also travel by bus. From Madrid. From Valencia. The bus station in Cuenca is 1.2 km from Hotel Torremangana.