The second law of thermodynamics dictates that Carnot limit is the maximal efficiency for the performance of a thermal machine. However, such upper bound can be only achieved when it operates reversibly and consequently delivering zero power. However, by working under nonequilibrium conditions thermal machines are able to generate useful work but producing finite entropy or dissipation. Such scenario has been analyzed from the point of view of the recently formulated thermodynamical relations, a new class of bounds that establish an inequality between the uncertainty or precision of currents and the entropy production involved. Thus, dissipation imposes certain limits for the precision of measurable currents that flow in a thermal machine. Such limits seem not being fulfilled by quantum machines in which inherent quantum advantages such as coherence or entanglement are able to circumvent them. Apart from the thermodynamic uncertainties that can be generalized to consider correlations between different currents in a system another kind of relations have been enunciated, the kinetic uncertainty relations that establish bounds for the precision of currents in a system that depend on the activity of a system, a inherently nonequilibrium property. Unifying these uncertainty relations and deriving others, the role of quantum advantages, generalization for time-dependent thermal machines, hybrid machines, maxwell demon machines, many-body interactions among others will be main targets of this minicolloquium.